Kedu ihe bụ Nitric Oxide?
Nitric oxide bụ gas na-emepụta site na mkpụrụ ndụ na-etinye aka na mbufụt metụtara nfụkasị ahụ ma ọ bụ eosinophilic asthma.
Kedu ihe bụ FeNO?
Nnwale nitric Oxide (FeNO) nke e kupụrụ ekupụrụ bụ ụzọ e si atụta ọnụọgụ nitric oxide n'ime ume ikuru.Nnwale a nwere ike inye aka na nchoputa nke ụkwara ume ọkụ site n'igosi ọkwa nke mbufụt na ngụgụ.
Utility Clinical nke FeNO
FeNO nwere ike ịnye ihe mgbakwunye na-adịghị emerụ ahụ maka nchọpụta mbụ nke ụkwara ume ọkụ na ATS na NICE na-akwado ya dịka akụkụ nke ụkpụrụ nduzi ha ugbu a na algọridim nyocha.
| Ndị okenye | Ụmụaka | |
| ATS (2011) | Oke:>50ppb Nke etiti: 25-50 pb Ala: <25 pb | Elu:>35ppb Nke etiti: 20-35 pb Ala: <20 pb |
| GINA (2021) | ≥ 20 pb | |
| Ọ dị mma (2017) | ≥ 40 pb | > 35 pb |
| Nkwekọrịta Scottish (2019) | > 40 ppb ICS-ndị ọrịa na-enweghị uche > 25 ppb ndị ọrịa na-ewere ICS |
Ndebiri: ATS, American Thoracic Society;FeNO, nitric oxide nke puru n'obere akụkụ;GINA, Global Initiative maka Asthma;ICS, corticosteroid inhaled;NICE, National Institute for Health and Care Excellence.
Ntuziaka ATS na-akọwapụta ọkwa FeNO dị elu, nke etiti na nke dị ala dị ka> 50 ppb, 25 ruo 50 ppb, na <25 ppb, n'otu n'otu.Mgbe n'ime ụmụaka, a na-akọwa ọkwa FeNO dị elu, ọkara na obere dị ka> 35 ppb, 20 ruo 35 ppb, na <20 ppb (Table 1).ATS na-atụ aro iji FeNO na-akwado nchoputa nke ụkwara ume ọkụ ebe a chọrọ ihe akaebe, karịsịa na nchoputa nke eosinophilic mbufụt.ATS na-akọwa na ọkwa FeNO dị elu (> 50 ppb na ndị okenye na> 35 ppb n'ime ụmụaka), mgbe a na-akọwa ya na ọnọdụ ahụike, na-egosi na eosinophilic mbufụt dị na nzaghachi corticosteroid na-anabata ndị ọrịa mgbaàmà, ebe ọkwa dị ala (<25 ppb na ndị okenye). na <20 ppb n'ime ụmụaka) na-eme ka nke a bụrụ nke a na-atụghị anya ya na ọkwa etiti kwesịrị iji nlezianya kọwaa ya.
Ntuziaka NICE dị ugbu a, nke na-eji ọkwa nkwụsị nke FeNO dị ala karịa ATS (Table 1), kwadoro iji FeNO dị ka akụkụ nke ọrụ nyocha ebe a na-atụle nchoputa nke ụkwara ume ọkụ na ndị okenye ma ọ bụ ebe enwere nchoputa ejighị n'aka na ụmụaka.A na-atụgharịkwa ọkwa FeNO ọzọ n'ọnọdụ ahụike yana nyocha ọzọ, dị ka nnwale mkpasu iwe nke bronchi nwere ike inyere nchoputa ahụ aka site n'igosi nnabata ikuku.Ntuziaka GINA na-ekwenye na ọrụ FeNO na-achọpụta na eosinophilic mbufụt na ụkwara ume ọkụ ma na-adịghị ahụ ugbu a ọrụ maka FeNO na asthma diagnostic algọridim.Consensus nke Scottish na-akọwa mbelata dị ka ikpughe steroid nwere ụkpụrụ dị mma nke> 40 ppb na ndị ọrịa steroid-naive na> 25 ppb maka ndị ọrịa na ICS.
Oge nzipu: Mar-31-2022